Artificial intelligence (AI) is reshaping modern healthcare by advancing disease diagnosis, treatment decision-making, and biomedical research. Among AI technologies, large language models (LLMs) have become especially impactful, enabling deep knowledge extraction and semantic reasoning from complex medical texts. However, effective clinical decision support requires knowledge in structured, interoperable formats. Knowledge graphs serve this role by integrating heterogeneous medical information into semantically consistent networks. Yet, current clinical knowledge graphs still depend heavily on manual curation and rule-based extraction, which is limited by the complexity and contextual ambiguity of medical guidelines and literature. To overcome these challenges, we propose an automated framework that combines retrieval-augmented generation (RAG) with LLMs to construct medical indicator knowledge graphs. The framework incorporates guideline-driven data acquisition, ontology-based schema design, and expert-in-the-loop validation to ensure scalability, accuracy, and clinical reliability. The resulting knowledge graphs can be integrated into intelligent diagnosis and question-answering systems, accelerating the development of AI-driven healthcare solutions.

We explore the potential of Large Language Models (LLMs) to assist and potentially correct physicians in medical decision-making tasks. We evaluate several LLMs, including Meditron, Llama2, and Mistral, to analyze the ability of these models to interact effectively with physicians across different scenarios. We consider questions from PubMedQA and several tasks, ranging from binary (yes/no) responses to long answer generation, where the answer of the model is produced after an interaction with a physician. Our findings suggest that prompt design significantly influences the downstream accuracy of LLMs and that LLMs can provide valuable feedback to physicians, challenging incorrect diagnoses and contributing to more accurate decision-making. For example, when the physician is accurate 38% of the time, Mistral can produce the correct answer, improving accuracy up to 74% depending on the prompt being used, while Llama2 and Meditron models exhibit greater sensitivity to prompt choice. Our analysis also uncovers the challenges of ensuring that LLM-generated suggestions are pertinent and useful, emphasizing the need for further research in this area.

Melanoma is a prevalent lethal type of cancer that is treatable if diagnosed at early stages of development. Skin lesions are a typical indicator for diagnosing melanoma but they often led to delayed diagnosis due to high similarities of cancerous and benign lesions at early stages of melanoma. Deep learning (DL) can be used as a solution to classify skin lesion pictures with a high accuracy, but clinical adoption of deep learning faces a significant challenge. The reason is that the decision processes of deep learning models are often uninterpretable which makes them black boxes that are challenging to trust. We develop an explainable deep learning architecture for melanoma diagnosis which generates clinically interpretable visual explanations for its decisions. Our experiments demonstrate that our proposed architectures matches clinical explanations significantly better than existing architectures.

Platelet products are both expensive and have very short shelf lives. As usage rates for platelets are highly variable, the effective management of platelet demand and supply is very important yet challenging. The primary goal of this paper is to present an efficient forecasting model for platelet demand at Canadian Blood Services (CBS). To accomplish this goal, four different demand forecasting methods, ARIMA (Auto Regressive Moving Average), Prophet, lasso regression (least absolute shrinkage and selection operator) and LSTM (Long Short-Term Memory) networks are utilized and evaluated. We use a large clinical dataset for a centralized blood distribution centre for four hospitals in Hamilton, Ontario, spanning from 2010 to 2018 and consisting of daily platelet transfusions along with information such as the product specifications, the recipients' characteristics, and the recipients' laboratory test results. This study is the first to utilize different methods from statistical time series models to data-driven regression and a machine learning technique for platelet transfusion using clinical predictors and with different amounts of data. We find that the multivariate approaches have the highest accuracy in general, however, if sufficient data are available, a simpler time series approach such as ARIMA appears to be sufficient. We also comment on the approach to choose clinical indicators (inputs) for the multivariate models.